News & Events
Structural and Chemical Insights into the Covalent-allosteric Inhibition of the Protein Kinase Akt
The Ser/Thr Kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal transduction pathways. Ist downstream signaling influences cell proliferation, cell growth, and apoptosis, rendering Akt a prominent drug target. The unique activation mechanism of Akt involves a change of the relative orientation of its N-terminal pleckstrin homology (PH) and the kinase domain and makes this kinase suitable for highly specific allosteric modulation. Here we present...
DDHD Meeting - Big Success
Thirty researchers of the DDHD consortium gathered at TU Dortmund University to enjoy an afternoon of excellent science and fruitful discussions.
TU Dortmund schlägt neues Kapitel in der Erfolgsgeschichte der Wirkstoffforschung auf
Universität eröffnet mit sieben Partnern Drug Discovery Hub Dortmund
Ein neues Kapitel in der außergewöhnlichen Erfolgsgeschichte der Dortmunder Wirkstoffforschung hat die TU Dortmund am Montag, 17. September, aufgeschlagen: In einer Feierstunde eröffneten Prof. Daniel Rauh, Koordinator des DDHD und Professor für Chemische Biologie und Medizinische Chemie an der TU Dortmund und Prof. Ursula Gather, Rektorin der TU Dortmund, den Drug Discovery Hub Dortmund (DDHD). ...
Read more … TU Dortmund schlägt neues Kapitel in der Erfolgsgeschichte der Wirkstoffforschung auf
RASPELD to Perform High‐End Screening in an Academic Environment toward the Development of Cancer Therapeutics
The identification of compounds for dissecting biological functions and the development of novel drug molecules are central tasks that often require screening campaigns. However, the required architecture is cost‐ and time‐intensive. Herein we describe the devices and technologies that comprise a Robotics‐Assisted Screening Platform for Efficient Ligand Discovery (RASPELD), which we set up in an academic laboratory. RASPELD provides semi‐automated high‐end screening, and it can be maintained by graduate students. ...
Chemical modulation of transcription factors
Transcription factors (TFs) constitute a diverse class of sequence-specific DNA-binding proteins, which are key to the modulation of gene expression. TFs have been associated with human diseases, including cancer, Alzheimer's and other neurodegenerative diseases, which makes this class of proteins attractive targets for chemical biology and medicinal chemistry research. ...